Key Technologies of 10-hydroxycamptothecin Extraction
Camptothecin production mainly includes three methods: natural extraction, total chemical synthesis, and semi-chemical synthesis. The CPT prepared by natural extraction is S shape and has high activity. However, because CPT has limited natural plant resources and less CPT content, it is easy to be affected by seasons and producing areas, which limits the wide application of this method. Natural extraction methods include the organic solvent method, alkali method, column chromatography method and resin adsorption method. The purity of the product is low and the color is deep, but the step is simple, the recovery is high and the post-processing is convenient. The extraction time is short and the extraction rate is high. The purity of the products obtained by the column chromatography and resin adsorption is high, but the yield is low and the steps are tedious. 1. Organic solvent extraction and extraction separation The raw material is pulverized with 70% to 90% ethanol as t...