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The roots of Polygonum cuspidatum contain anthraquinones, flavonoids, coumarin, lignans and some other polyphenols. At present, many scholars at home and abroad have studied the chemical composition of Polygonum cuspidatum more deeply. In the early study, most of them were concentrated in anthraquinone and two styrene components. These two components are considered to be the main active substances of Polygonum cuspidatum. In recent years, two styrene compounds in Polygonum cuspidatum have been found to have strong antioxidant, antitumor activity and effect on the cardiovascular system, especially the resveratrol, which is the main antioxidant in grape and wine, has been widely recognized, and Polygonum resveratrol has been paid much attention to. Polygonum cuspidatum has become a medical treatment in recent years. One of the hottest plants in the field of medical research has been carried out in many aspects. In the process of finding insecticidal active substances from plants, we

Besides the significant cholinesterase inhibition, Hup A also has extensive neuroprotective effects. Its protective effect also plays an important role in the treatment of AD and the damage of neurotoxic substances. 1 antagonism to organophosphorus neurotoxicity: organophosphorus compounds are a very toxic class of neurotoxic agents, which can irreversible the inhibition of acetylcholinesterase in the central and peripheral areas. The main mechanism of Hup A against organophosphorus poisoning is the reversible binding of Hup A to acetylcholinesterase in advance, thus preventing the irreversible binding of organophosphorus compounds from acetylcholinesterase. Compared with other used reversible cholinesterase inhibitors, such as bromide pyridine, Hup A has two advantages: on the one hand, Hup A can protect the brain acetylcholinesterase through the blood-brain barrier. Animal experiments show that Hup A can effectively protect the cerebral cortex cholinesterase from Souman inhibi

1 Anti AChE effect and its mechanism: the interaction mechanism and mode of Hup A and AChE are deeply studied by means of the dynamic method, computer-aided molecular docking design, and X-ray crystal diffraction. Hup A can inhibit AChE by binding to AChE. In vitro experiments showed that the binding of Hup A to AChE was reversible, and AChE could be recovered after Hup A was released. AChE has stereoselectivity for Hup A recognition, Hup A can effectively inhibit AChE, while Hup A has no substantial inhibition effect. The minimum effective dose of Hup A to rat cerebral cortex AChE was 10 nmol / I., and the inhibitory effect was a typical mixed competitive inhibition. The inhibitory effect of Hup A on butyl cholinesterase (BuChE) in rat plasma is weak. Because of the significant difference between the inhibitory intensity of AChE and BuChE in the Hup A, the level of acetylcholine in the brain is significantly increased and the external effect is not obvious, thus reducing the side